A Cure for Premenstrual Syndrome (PMS)

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by James Goodwin, M.D.

Is there any other drugs to worry about while I'm on progesterone?

Estrogens

PMS is caused by too much estrogen.

Women produce estrogen themselves from the follicles on their ovaries. Estrogen is also produced by the fat cells. In fact, an obese women after menopause produces more estrogen than a skinny women before menopause. In fact, after menopause, estrogen production drops to only 60% of premenopause levels. However, progesterone levels drop almost to zero compared to premenopause levels.

Taking Natural Progesterone will resensitize the estrogen receptors to estrogen so that your body will become more sensitive to estrogen supplemements.

Dr. Lee reccommends to immediately cut the dose of estrogen to one half, and DISCONTINUE estrogen supplements altogether over a period of 3-4 months.

Progestins

Dr. Lee maintains that a woman on a progestin such as Provera (Medroxyprogesterone acetate) or Megestrol should stop the progestin. Immediately lower the dose by 1/2 and lower it more the second month. By the third month the progestin may be completely stopped. There are two reasons for this method.

The first reason is that the progestin competes for the binding sites of progesterone. Thus, continued use of the progestin will block the effect of progesterone.

The second reason is that plasma progesterone levels will not reach a maximum level until the 2nd or 3rd month of use. Initially, in progesterone deficient patients, much of the progesterone is absorbed into body fat. With continued use, fat levels of progesterone reach an equilibrium such that successive doses of progesterone result in increased blood levels and stronger physiological effects. Thus, progesterone applications may take 2 to 3 months before the maximum benefits are experienced.

Thyroid

Cellular utilization of thyroid hormone is impeded by estrogen and promoted by progesterone. Thus, when using progesterone and cutting back on estrogen supplementation thyroid hormone is more efficiently utilized by the body. For patients taking thyroid hormone, the dosage may need to be cut back.

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