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What kind of progesterone cream should I use and how should
I use it?
John Lee, M.D. uses 10 mg - 50 mg of natural progesterone per day
applied twice daily in a cream applied topically in a ten day period, ending just before expected menses. This
cream does not contain herbs, wild yams, or progestins such as Provera (Medroxyprogesterone acetate) or Megestrol.
Some herbs used in the creams contain estrogens that are made by plants known as phytoestrogens such as Clary Sage.
These Phytoestrogens may actually exacerbate PMS and this exacerbation has been seen in some patients.
The skin cream should contain 500 mg - 1000mg Natural Progesterone per
ounce of cream. The cream should not contain any mineral oil. Mineral oil blocks the absorption of Natural Progesterone
into the body. The vast majority of Natural Progesterone is made from yams or soy which contain the base molecule
of progesterone in it. Yams are NOT the same as Natural Progesterone and will not have the same effect.
Progesterone and estrogen used as birth control pills were discovered
by the pharmaceutical companies while looking for a fertility drug by studying folk medicine in Mexico. Wild yams
were found to have a diosgenin that had the base compound of progesterone in it. The Drug Companies cannot patent
a natural compound such as progesterone. Progesterone is what the human body naturally produces on the Corpus Luteum
of the ovary and the placenta. The Drug Companies purposely alter progesterone adding extra molecules to the it.
In this way, the resultant molecule can be patented and money can be made. Because of these alterations to the
molecule, the drug has side effects. The following is a partial list of side effects of Provera (medroxyprogesterone
acetate) from 1993 PDR (Physician's Desk Reference):
WARNING:
Increased risk of birth defects such as heart and limb defects if
taken during the first four months of pregnancy.
Beagle dogs given this drug developed malignant mammary nodules.
Discontinue this drug if there is a sudden or partial loss of vision.
This drug passes into breast milk consequences unknown.
May contribute to thrombophlebitis, pulmonary embolism, and cerebral
thrombosis.
PRECAUTIONS
May cause fluid retention, epilepsy, migraine, asthma, cardiac or
renal dysfunction.
May cause breakthrough bleeding or menstrual irregularities.
May cause or contribute to depression.
The effect of prolonged use of this drug on pituitary, ovarian,
adrenal, hepatic, or uterine function is unknown.
May decrease glucose tolerance; diabetic patients must be carefully
monitored.
May increase the thrombotic disorders associated with estrogens.
The Drug Companies produce Progestins such as Provera and Megestrol by growing yams in large commercial farms and
then chemically processing the yams to alter the diosgenin to their patented drug.
Since progesterone is natural it cannot be patented and is sold
over the counter by many companies. You do not need a prescription for the small amount of progesterone in the
cream. The cream should not contain mineral oil since Dr. Lee has had anecdotal experience that the mineral oil
tends to block absorption. Dr. Lee uses a concentration of 500 mg of progesterone per oz. So a two ounce bottle
contains 1000 mg of progesterone. Use 1/4 of the 2 ounce bottle to the whole 2 ounce bottle every month. Refrigeration
of the bottle may help slow down the breakdown of the progesterone in the bottle when it comes in contact with
air. He uses 10 mg - 50 mg per day applied topically in the morning and night on the ten days just prior to menses.
The progesterone cream may rubbed on the skin at any site having good circulation such as the palms and soles of
the feet, back of the neck, thighs,face, upper chest and abdomen. Rotate between areas. I have found that for women
weighing about 100 pounds a dose of 10 mg may be more appropriate. If the dose of progesterone is too high, a woman
might feel elated and then when the progesterone is stopped the woman may feel depressed. If this is the case,
cut back on the dose of progesterone. The correct dose of progesterone is the one that works. Some women increase
the dose to produce a crescendo effect 4-5 days prior to menses. Again the correct dose is the one that works.
There is one hypothesis that the cessation of progesterone is what
causes post partem blues. The placenta produces as much as 400 mg of progesterone per day. After birth, the production
of progesterone markedly decreases with a resultant biochemical caused psychological depression.
Topical application allows good absorption of progesterone much
like the estrogen patches used by the pharmaceutical companies. The level of active progesterone may be followed
by using a saliva test. A blood test will not show the levels because transdermal progesterone travels on the surface
of the red blood cell and the chylomicrons. Topical application doses are much lower than that of the oral dose.
In the oral dose, the progesterone is filtered and process by the liver and 80% to 90% is first pass inactivated
by the liver. Thus, 80% to 90% of the oral dose of progesterone never reaches the body.
In summary, use 10 mg - 50 mg of progesterone cream on the
10 days just prior to menses. Adjust the dose until you find the correct dose for you.
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Contact drjamesmd@juno.com for more information.
 
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